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Key Starting Materials & Advanced Intermediates

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Intermediate is a kind of material produced in the process of API, which can only be turned into API by further molecular change or refinement. Intermediates can be separated or not separated.API is Active Pharmaceutical Ingredients. 

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Bulk drug intermediates are the drugs used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API.

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Azacus can provide access to the following intermediates

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API INTERMEDIATE NAME CAS NO

 

Used for API : Rocuronium Bromide

  • Intermediate 1:(2b,3a,5a,16b,17b)-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane-3,17-diol

CAS : 119302-20-4

  • Intermediate 2 : (2b,3a,5a,16b,17b)-17-Acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane

CAS 119302-24-8

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Used for API : Voglibose

  • Intermediate 1: Tetrabenzyl-voglibose

CAS : 115250-39-0

  • Intermediate 2 : 2,3,4,6-tetra-O-benzyl-D-glucopyranose

CAS 6564-72-3

 

Used for API :Entecavir

  • Intermediate 1 : Entecavir E3

CAS 701278-56-0

  • Intermediate 2: Entecavir E7

CAS 204845-95-4

  • Intermediate 3: Entecavir E8

CAS 142217-81-0

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Used for API :Vildagliptin

  • Intermediate 1: 3-Amino-1-adamantanol

CAS 702-82-9

  • Intermediate 2: L-Prolinamide

CAS 7531-52-4

  • Intermediate 3: 1-Adamantanamine hydrochloride

CAS 665-66-7

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Used for API :Sitagliptin Phosphate

  • Intermediate 1 : 3-trifluoromethyl-[1,2,4]triazole[4,3-a]piperazine hcl CAS 762240-92-6

  • Intermediate 2: [[(1,1-dimethylethoxy)carbonyl]amino]-2,4,5-trifluoro--(R)-benzenebutanoic acid

CAS 486460-00-8

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Used for API :Canagliflozin

  • Intemediate 1 : 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone

CAS 32384-65-9

  • Intermediate 2: Tetra Acetyl Canagliflozin

CAS 866607-35-4

  • Intermediate 3: Canagliflozin hemihydrate

CAS 928672-86-0

  • Intemediate 4: 2-((5-bromo-2-methylphenyl)methyl)-5-(4-fluorophenyl)thiophene

CAS 1030825-20-7

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Used for API : Dapagliflozin propanediol monohydrate

  • Intermediate 1: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol tetraacetate

CAS 461432-25-7

 

Used for API :Empagliflozin

  • Intermediate 1: (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydro-furan

CAS 915095-89-5

  • Intermediate 2: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol tetraacetate

CAS 915095-99-7

  • Intermediate 3: Repaglinide (S)-3-Methyl-1-(2-piperidinophenyl)butylamine-N-acetylglutamate salt

CAS 219921-94-5

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Used for API :Rivaroxaban

  • Intermediate 1 : 4-(4-Aminophenyl)morpholin-3-one 438056-69-0(S)-(+)-N-(2,3-Epoxypropyl) phthalimide

CAS 161596-47-0

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Used for API :Prasugrel

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  • Intermediate 1: 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2(4H)-one hydrochloride

CAS 115473-15-9

  • Intermediate 2 : (1R trans)-2-(3,4-difluorophenyl)cyclopropane aminehydrochloride

CAS 1156491-10-9

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Used for API :Ibrutinib

  • Intermediate 1: 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylamine

CAS 330786-24-8

  • Intermediate 2: 4-Chloropyrrolo[2,3-d]pyrimidine 3680-69-1(S)-(+)-3-Hydroxytetrahydrofuran

CAS 86087-23-2

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Used for API :Mirabegron

  • Intermediate 1: (R)-2-[[2-(4-nitrophenyl ethyl] aMino]-1-phenyl ethanol Monohydrochloride

CAS 521284-21-9

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Used for API :Suvorexant

  • Intermediate : 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

CAS 956317-36-5


Synonyms:5-Chloro-2-((R)-5-Methyl-[1,4]diazepan-1-yl)benzooxazole hydrochloride

CAS 1266664-66-7

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Used for API :Apremilsat

  • Intermediate : (alphaS)-3-Ethoxy-4-methoxy-alpha-[(methylsulfonyl)m
    CAS 608141-42-0

  • ethyl]-benzenemethanamine

 

Used for API :Ticagrelor

  • Intermediate 1: 2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH

CAS 376608-65-0

  • Intermediate 2: (1R,2R)-2-(3,4-difluorophenyl)
    cyclopropanamine(S)-(carboxylato(phenyl)
    methyl)holmium
    CAS 376608-71-8

  • -cyclopenta[d][1,3]dioxol-4-yloxy)ethanol L-tataric acid

 

  • Intermediate 3: 2-[[(3aR,4S,6R,6aS)-6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-Ethanol

CAS 376608-74-1

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Used for API :Obeticholic Acid

  • Intermediate 1: 3-alpha-hydroxy-7-oxo-5-beta-cholan-24-oic acid CAS 4651-67-6

  • Intermediate 2: (3alpha,5beta,6E)-6-Ethylidene-3-hydroxy-7-oxocholan-24-oic acid

CAS 1516887-33-4

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Used for API :Silodosin

  • Intermediate 1 : 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl

CAS 160969-03-9

  • Intermediate 2: 5-[(2R)-2-aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dih

ydro-7-carbonitrile-1H-indole
(2R,3R)-2,3-dihydroxybutanedioate (1:1)
CAS 239463-85-5

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Used for API :Eplerenone hcl

  • Intermediate : Pregna-4,9(11)-diene-7,21-dicarboxylic

CAS 95716-70-4

  • Intermediate 2: 11-a-Hydroxy canrenone methyl ester acid,17-hydroxy-3-oxo-g-lactone,methyl ester

CAS 192704-56-6

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Used for API :Ledipasvir

  • (1R,3S,4S)-3-[6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-
    2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]heptane-
    2-carboxylic acid 1,1-dimethylethyl ester

CAS 1256387-87-7

  • Intermediate 2: (1R,3S,4S)-N-Boc-2-azabicyclo[2.2.1]heptane-3-carboxyl
    CAS 291775-59-2
     

  • Intermediate 3: (S)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-ca
    rboxylic acid
    CAS 1129634-44-1

  • Intermediate 4: (6S)-6-[5-(7-Bromo-9,9-difluoro-9H-fluoren-2-yl)-1H-imi​dazol-2-yl]-5-azaspiro[2.4]heptane-5-carboxylic acid

CAS 1441670-89-8

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Used for API :Velpatasvir

  • Intermediate 1: (2S,5S)-N-Boc-5-methylpyrrolidine-2-carboxylic acid CAS 334769-80-1

  • Intermediate 2: (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid

CAS 1378388-16-9

  • Intermediate 3: 
    9-Bromo-3-(2-BromoAcetyl)-10,11-Dihydro-5H-dibenzo(c,g)

  • CAS 1438383-89-1
    Intermediate 4: 3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chrom
    en-8(9H)-one
    CAS 1378390-29-4

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Used for API :LCZ696

  • Intermediate : (R)-tert-butyl(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate

  • CAS 1426129-50-1

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LCZ696

 

  • Intermediate 1: (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)am

CAS 1012341-48-8

  • Intermediate 2: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

CAS 1012341-50-2

  • Intermediate 3: (2R,4S)-ethyl-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride

CAS 149690-12-0

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Used for API :Dabigatran etexilate mesylate

  • Intermediate 1: 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-yl -amino]propionicacid ethyl ester

CAS 211915-84-3

  • Intermediate 2: 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER

CAS 212322-56-0

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Used for API :Edoxaban TsOH

  • Intermediate 1: tert-Butyl[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbo
    CAS 1210348-34-7

  • Intermediate 2: 5-methyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carboxylic acid,hydrochloride

CAS 720720-96-7

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Used for API :Febuxostat

  • Intermediate 1: Ethyl-2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazol
    CAS 160844-75-7

  • Intermediate 2: Ethyl-2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate

CAS 161798-01-2

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Used for API :Deflazacort

  • Intermediate 1: 21-Deacetoxy Deflazacort/(D5/D8)

  • CAS 13649-88-2

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Used for API :Finasteride

  • Intermediate 1: Methyl 3-oxo-4-androstene-17beta-carboxylate/(F4) 2681-55-23-oxo-4-aza-5A-androstane-17B-(N-T-butylcarboxamoyl)/(F9)

CAS 98319-24-5

  • Intermediate 2: Methyl-4-aza-5alpha-Androsta-3-one-17beta-Carboxylate/(M3)

CAS 73671-92-8

  • Intermediate 3: 3-Oxo-4-aza-5-alpha-androstane-17-beta-carboxylicacid/ (M3 acid)

CAS 103335-55-3

  • Intermediate 4: Methyl-4-aza-5alpha-Androsta-1-en-3-one-17beta-Carboxylate /(M4)

CAS 103335-41-7

  • Intermediate 5: 4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid/(M4 Acid)

CAS 104239-97-6

  • Intermediate 6: 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone/ (DDQ)

CAS 84-58-2

 

Used for API :Pidotimod

  • Intermediate 1: L(-)-Thiazolidine-4-carboxylic acid

CAS 34592-47-7

  • Intermediate 2: Ethyl L-thiazolidine-4-carboxylate hydrochloride

CAS 86028-91-3

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Used for API :Vonoprazan fumarate

  • Intermediate 1: 3-Pyridinesulfonyl chloride

CAS 16133-25-8

  • 5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde

CAS 881674-56-2

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Used for API :Rosuvastatin Calcium

  • Intermediate 1: R1

CAS 289042-12-2

  • Intermediate 2: R2

CAS 355806-00-7

  • Intermediate 3: Rosuvastatin methyl ester

CAS 147118-40-9

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Used for API :Pitavastatin Calcium

  • Intermeidate : t-Butyl(3R,5S)-7-[2-cyclopropyl-4-(4-luorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate
    CAS 147489-06-3

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